Thus, topical calcipotriene may be used as an alternative or adjunct to topical corticosteroid therapy. It is applied twice daily when used as monotherapy. No controlled trials guide how best to use topical corticosteroids in conjunction with calcipotriene. Once daily use of each may be adequate. Acidic products can inactivate topical calcipotriene, and some topical corticosteroids may be acidic. A reasonable approach to combination therapy is to have patients apply topical calcipotriene and topical corticosteroids each once daily at different times of day.
Science is said to be a theoretical, empirical and practical knowledge of the natural world. The knowledge is said to be obtained by use of research findings through observations, explanation, and experimentation of the actual phenomena. Given that scientific researches insist on objective knowledge, it has improved the recent researches on the concept of stress, and has done much in improving the history of stress. The scientific advancements are considered to be very crucial and it considers earlier researches as being "pre-scientific." it has therefore brought about many changes in the history of stress by forcing the current researchers on the topic of stress, to come up with what they call scientific and up to date research findings on stress. Social advancements have also depicted a major impact on the history of stress. The last 20 years have registered significant changes in the structure of the society. This is because of the demographic developments, technological advancements, and socio-economic changes. These in turn have affected our family structures, social networks, and our working patterns. These changes have been said to have increased the levels of stress and the causes of stress as well. This has therefore raised a new challenge of addressing the structural changes and how they affect the life of a human being. This is because in the early history of stress, such issues as society structures and technological advancements were not considered (Aldwin, ., ed., 1993, ).